Epigenetics of Depression

Natural and inherited factors have a significant impact on major depressive illness. These elements include epigenetic modification of the genome, which involves a continuous change in quality expression without a modification of the actual DNA sequence. Although an individual is typically defenceless during childhood, hereditary and natural factors can have long-lasting effects on the genome. Methylation is one epigenetic factor that may serve as an indicator of how effective a given antidepressant treatment is. Antidepressants are currently used to reduce global DNA methylation levels and to calm people's moods.

  • Major depressive disorder
  • Gene expression
  • Brain-derived neurotrophic factor

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